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Clomipramine is a psychotropic agent used to treat obsessive-compulsive disorder (OCD). Clomipramine shares structural similarities with a class of antidepressants known as tricyclic antidepressants (TCAs). The exact mechanism by which Clomipramine exerts its therapeutic benefits is not fully understood. However, similar to other TCAs, Clomipramine is thought to enhance the actions of norepinephrine and serotonin (chemical neurotransmitters in the brain that nerves use to communicate with one another) by blocking their reuptake and prolonging their activity. Clomipramine also has anticholinergic properties which means it blocks the action of another neurotransmitter, acetylcholine. This increases the risk for certain side effects. It also has weak antihistamine properties which appear to play a role in the mild sedative effects observed with use. Clomipramine was approved by the US FDA for the treatment of OCD in 1991.

Other names for this medication:
Clomipramine, Anafranil, Clofranil, Clomipramina, Clora, Zenil,

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Clomipramine is used to treat obsessive compulsive disorder (OCD). OCD is a nervous condition wherein a person has recurring thoughts or ideas or does repetitive things because they are anxious.

Clomipramine is a tricyclic antidepressant (TCA). It is thought to work in the brain by increasing the activity of the chemical serotonin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule

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Data were obtained from the 2006 Medical Expenditure Panel Survey (MEPS). Some subcutaneous foreign bodies (FBs) are not easily visualized during physical examination and may not be detected on radiographic evaluation. This synthesis provides a simple and highly reproducible method for the preparation of Cu(2)S nanocrystals that may find potential applications in the fabrication of photovoltaic devices.

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In order to obtain the global proteome interaction map of Wt1, an unbiased label-free endogenous immunoprecipitation was performed followed by mass spectrometry to identify protein interactions that are Wt1 centric. ZA is promising when combined with sorafenib to enhance its antitumor effect. Collagen fibril surface displays a constellation of sites capable of promoting fibril assembly, stability, and hemostasis. The effect of coal dust with an admixture of shale on the development of experimental pneumoconiosis

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Although most of these agents are associated with reduced thyroid hormone levels or impaired thyroid hormone action, a number of environmental exposures confer an increased risk of autoimmune thyroid disease. This may assist clinical management of AML given evidence that fat content predicts embolization response.

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Probe measurements of intratumoral Po(2) were compared with the image data. Diabetic nephropathy (DN) is a major complication of diabetes mellitus (DM) affecting individuals with type 1 or type 2 DM and is the leading cause of chronic kidney disease and end-stage kidney disease (ESKD) in the USA. Paracelsus and formaldehyde 2010: the dose to the target organ makes the poison. Identification of protease m1 zinc metalloprotease conferring resistance to deltamethrin by characterization of an AFLP marker in Culex pipiens pallens.

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Exploring cell tropism as a possible contributor to influenza infection severity. Accordingly, the formation of NO in platelets by 3-oxo-2,3-dihydrobenzofuran-6,7-diyl diacetate (3a) was found to be comparable with that of model polyphenolic acetate (PA), 7,8-diacetoxy-4-methylcoumarin (DAMC).

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This transcription represents the intracellular enzymatic activity of the virion-associated polymerase and is shown to be dependent on input multiplicity. 3DRA has emerged as a promising tool for improved visualization of cardiac and vascular structures in congenital heart disease. Finally, we also tested depressive signs by means of sucrose consumption, and anhedonia was found in LD males treated with MEL. Determination of different recreational drugs in sweat by headspace solid-phase microextraction gas chromatography mass spectrometry (HS-SPME GC/MS): Application to drugged drivers.

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The cross-sectional study involved administration of an adapted and pretested questionnaire to 601 consented patients attending the two tertiary health institutions in Bayesla State. Leptadenia pyrotechnica (Forssk.) Decne (Asclepiadaceae) is a well-renowned medicinal shrub, used by herbal practitioners for various ailments including allergic rhinitis, productive cough, abortion, diabetes, stomach disorders, fever, kidney disorders, stones and cancer The Effects of a Multidisciplinary Care Conference on the Quality and Cost of Care for Lung Cancer Patients.

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Before LGN inactivation, high-contrast stimuli presented to the lesion-affected visual field (scotoma) produced significant V1-independent fMRI activation in the extrastriate cortical areas V2, V3, V4, V5/middle temporal (MT), fundus of the superior temporal sulcus (FST) and lateral intraparietal area (LIP) and the animals correctly located the stimuli in a detection task. Lung disease associated with marked peripheral blood eosinophilia is unusual and nearly always clinically significant. A successful elucidation of the near-ultraviolet electronic circular dichroism spectrum of a short double-stranded DNA is reported. Members of this unique virtual advisory board engaged in a structured Web-based communication process that identified the most important community-specific COPD care coordination research topics and questions.

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Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries. Tumour uptake was analysed with a kinetic two-compartment model for estimation of pharmacokinetic parameters. albicans germ tube formation and enzyme (protease, phospholipase, and aspartate dehydrogenase) activity. Ozone administration resulted in significant reduction of glutathione peroxidase activity, plasma zinc levels and plasma and Red Blood Cells antioxidant capacity. Quality by Design Applied to Ocular Solid Lipid Nanoparticles Containing a Hydrophilic Peptide Prepared via Hot High Pressure Homogeniser.

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A note on the polytene nuclei in the fat body of Drosophila larvae. Density Detection of Aligned Nanowire Arrays Using Terahertz Time-Domain Spectroscopy. Both of these changes lead to the increase of the number of C8E3 molecules being in a direct contact (i.e., forming hydrogen bonds) with water. The aim of this commentary is to discuss the opportunities and challenges of incorporating PrEP into the Brazilian continuum of HIV care and prevention for men who have sex with men (MSM) and TGW.

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The biological effects of these low doses of IR on the healthy tissue surrounding the tumor area, and in particular on the vasculature remain largely to be determined. Paradigms learnt from managing ALPS patients in recent years is highlighted here and can be extrapolated to manage refractory cytopenias in patients with as yet undetermined genetic bases for their ailments. He had subsequent development of respiratory failure on the seventh hospital day.

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Performance of the Sysmex UF-1000i urine analyser in the rapid diagnosis of urinary tract infections in hospitalized patients. These results confirm the first hypothesis and partially support the second hypothesis.

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Gastroesophageal reflux disease (GERD), including erosive reflux disease and non-erosive reflux disease (NERD), is a chronic disease with a significant negative effect on quality of life. Here, we describe a simple mechanistic model of STP, derived in large part from basic principles of synaptic function, that reproduces this highly nonlinear synaptic behavior. The visualizations provide information on the geographic traffic of the spread of the pathogens and places that are hubs for their transport. Importantly, these near-record capacities are reversible for at least three cycles. The heart in rheumatoid arthritis: contrasting or misleading data from clinical research?

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Effect of Cationic Surfactant Head Groups on Synthesis, Growth and Agglomeration Behavior of ZnS Nanoparticles. Schizophrenia and task orientation: the structured ward setting. APF530 versus the standard three-drug regimen provided superior control of delayed-phase CINV following HEC. Thus, the number and function of EPCs could be intimately associated with the population and functional status of stem cells (SCs) in the BM. Using two mouse models of ear skin inflammation (histamine- and IgE-mediated passive cutaneous anaphylaxis) we topically applied fingolimod prophylactically, as well as after establishment of the inflammatory response, and examined ear swelling, SK activity, vascular permeability, leukocyte recruitment, and production of proinflammatory mediators.

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Abnormal regulation of this process is associated licoprima forte cotrimoxazole with developmental and degenerative neuronal disorders. We discuss the clinical manifestations, pathophysiologic mechanisms, and associations of cutaneous macular amyloidosis. The pro-inflammatory mediators tumour necrosis factor alpha, interleukin-beta and nitric oxide play a significant role in sepsis-related hypotension, shock and depression of cardiomyocyte contractility. In order to successfully eradicate GBM growth and recurrence, new anti-cancer strategies selectively targeting CSCs should be designed. Therefore, the present study was carried out to elucidate iron metabolism in Atp7b(-/-) mice, an animal model of Wilson disease.

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Inhibitory effects of a dendritic cell vaccine loaded with radiation-induced apoptotic tumor cells on tumor cell antigens in mouse bladder cancer. Our results therefore suggest that mutations conferring resistance to targeted therapy occur naturally in normal and malignant cells and these mutations do not arise as a result of the increased mutagenic plasticity of cancer cells. CSF Pulsation Artifacts on ADC Maps Obtained with Readout-segmented EPI. The overall structures and internal structural changes of NCPMs and CPMs in aqueous solution were studied in detail aripiprazole 2 mg tablet using synchrotron X-ray scattering method.