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PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa. The simulations highlight the major collective coordinates generating the opening and the closing of the two SH3 domains and the residues that cause the unmasking of the p22(phox) binding site. Patients with plasma CRP and copeptin levels higher than median values had worse prognoses. Therefore, posttranslational modifications of mitochondrial proteins by MGO may represent pathogenic events leading to mitochondria-induced oxidative stress in the kidney in chronic diabetes.

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